Reducing indeterminate thyroid FNAs
نویسندگان
چکیده
منابع مشابه
Thyroid Nodules with Indeterminate Cytology
To the Editor: Alexander et al. (Aug. 23 issue)1 report findings from a prospective, multicenter gene-expression classifier validation study that raises several questions. For the 265 indeterminate fine-needle aspirates they tested, the geneexpression classifier had a sensitivity of 92%, a specificity of 52%, a positive predictive value of 47%, and a negative predictive value of 93%. Why the ob...
متن کاملLocal molecular analysis of indeterminate thyroid nodules
BACKGROUND Thyroid nodules are common but only a minority are malignant. Molecular testing can assist in helping determine whether indeterminate nodules are suspicious for malignancy or benign. The objective of the study was to determine if the analysis of mutations (BRAF, NRAS, KRAS and HRAS) using readily available molecular techniques can help better classify indeterminate thyroid nodules. ...
متن کاملValue of repeated fine needle aspirations of the thyroid: an analysis of over ten thousand FNAs.
OBJECTIVE Fine needle aspiration (FNA) has been accepted as the diagnostic method of choice in the initial evaluation of thyroid nodules. However, the value of repeated FNAs in the long-term follow-up of lesions initially diagnosed as benign is being questioned. Do the findings on initial FNA really spare patients thyroidectomy or do they only postpone it? The purpose of the present study is ou...
متن کاملA Pragmatic Approach to the Indeterminate Thyroid Nodule
Thyroid nodules are prevalent in upto 68% of randomly selected individuals in whom high resolution ultrasound is performed. The majority of nodules are benign. The use of ultrasound coupled with FNAC has dramatically reduced the number of patients who undergo surgery for nodules. The six tier Bethesda scoring system has reduced variability and increased the ability to clinicians to guide patien...
متن کاملDiagnostic Value of RAS Mutations in Indeterminate Thyroid Nodules.
Objectives To determine the diagnostic value of HRAS, KRAS, and NRAS mutations in fine-needle aspiration biopsies of thyroid nodules that are nondiagnostic on cytology. Data Sources PubMed, Scopus, Embase, CINAHL. Review Methods Two authors independently searched the data sources. To be included, studies reported the RAS mutational status and postoperative histopathologic diagnosis of nodules t...
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ژورنال
عنوان ژورنال: Cancer Cytopathology
سال: 2015
ISSN: 1934-662X
DOI: 10.1002/cncy.21520